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CDK9 (Thr186) Antibody

CDK9 (Thr186) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCDK9 (Thr186) Primary Polyclonal Antibody
Also known asCDK9 (Thr186) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCDK9 Thr186
SpecificityThis is a highly specific antibody against CDK9 Thr186
Modification(s)Phosphorylation
Modification site(s)Thr186
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human CDK9 around the phosphorylation site of Thr186
Gene ID number1025
Swiss ProtP50750
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, In addition, MYOD1, Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), P-TEFb is also involved in cotranscriptional histone modification, Phosphorylates EP300, Promotes RNA synthesis in genetic programs for cell growth, Promotes cardiac myocyte enlargement, RPB1/POLR2A and AR, Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e, Replication stress response protein, SUPT5H and RDBP, TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling), The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro, This complex is inactive when in the 7SK snRNP complex form, also called positive transcription elongation factor b (P-TEFb), and the negative elongation factors DSIF and NELF, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, differentiation and viral pathogenesis, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing, mRNA processing and mRNA export, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6, the CDK9/cyclin-K complex is required for genome integrity maintenance, thus reducing the breakdown of stalled replication forks and avoiding DNA damage, which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, Protein kinase involved in the regulation of transcription, g
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C-2k, CDC2L4, CDK9, CTK1, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Cyclin-dependent kinase 9, PITALRE, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, TAK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCDK9 (Thr186)
Short nameCDK9 (Thr186) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCDK9 (Thr186) (Antibody to)
Alternative techniqueantibodies
Identity 1780
Gene CDK9
Long gene name cyclin dependent kinase 9
Synonyms gene CDC2L4
Synonyms gene name cyclin-dependent kinase 9 (CDC2-related kinase)
Synonyms PITALRE C-2k TAK
Locus 9q34, 11
Discovery year 1998-04-29
GenBank acession L25676
Entrez gene record 1025
Pubmed identfication 8170997 9356449
Classification Cyclin dependent kinases P-TEFb complex
Havana BLAST/BLAT OTTHUMG00000020715

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