Filters

CDK9 (Thr186) Antibody, ALEXA FLUOR 488

CDK9 (Thr186) Antibody, ALEXA FLUOR 488 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, CDK9 (Thr186) Polyclonal Antibody
Also known asAnti-CDK9 Thr186 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenCDK9 Thr186
SpecificityThis is a highly specific antibody against CDK9 Thr186
ModificationPhosphorylation
Modification SiteThr186
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human CDK9 around the phosphorylation site of Thr186
Gene ID Number1025
Swiss ProtP50750
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, In addition, MYOD1, Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), P-TEFb is also involved in cotranscriptional histone modification, Phosphorylates EP300, Promotes RNA synthesis in genetic programs for cell growth, Promotes cardiac myocyte enlargement, RPB1/POLR2A and AR, Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e, Replication stress response protein, SUPT5H and RDBP, TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling), The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro, This complex is inactive when in the 7SK snRNP complex form, also called positive transcription elongation factor b (P-TEFb), and the negative elongation factors DSIF and NELF, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, differentiation and viral pathogenesis, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing, mRNA processing and mRNA export, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6, the CDK9/cyclin-K complex is required for genome integrity maintenance, thus reducing the breakdown of stalled replication forks and avoiding DNA damage, which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, Protein kinase involved in the regulation of transcription, g
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms PITALRE C-2k TAK
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the CDK9 (Thr186) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetCDK9 (Thr186)
Short nameCDK9 (Thr186) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, CDK9 (Thr186) (Antibody to)
Alternative techniqueantibodies
Identity 1780
Gene CDK9
Long gene name cyclin dependent kinase 9
Synonyms gene CDC2L4
Synonyms gene name cyclin-dependent kinase 9 (CDC2-related kinase)
Locus 9q34, 11
Discovery year 1998-04-29
GenBank acession L25676
Entrez gene record 1025
Pubmed identfication 8170997 9356449
Classification Cyclin dependent kinases P-TEFb complex
Havana BLAST/BLAT OTTHUMG00000020715

Similar products

Subscribe to our Newsletter