| Long name | 4, 4) Monoclonal Antibody, CDKN1A (592CT11 |
| Also known as | 4, 4) Monoclonal Antibody, CDKN1A (592CT11 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CDKN1A |
| Specificity | This is a highly specific antibody against CDKN1A |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 4, 4, 592CT11 |
| Source | This CDKN1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human CDKN1A |
| Gene ID number | 1026 |
| Swiss Prot | P38936 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:100~250) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | At higher stoichiometric ratios, Binds to and inhibits cyclin-dependent kinase activity, Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1, inhibits the kinase activity of the cyclin D-CDK4 complex, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression, May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage |
| Purification method | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CAP20, CDK-interacting protein 1, CDKN1, CDKN1A, CIP1, Cyclin-dependent kinase inhibitor 1, MDA-6, MDA6, Melanoma differentiation-associated protein 6, PIC1, SDI1, WAF1, p21CIP1, P21 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 4, 4) Monoclonal, CDKN1A (592CT11 |
| Short name | 4, 4) Monoclonal Antibody, CDKN1A (592CT11 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Cip1) (592CT11, 4, 4) monoclonal (Antibody to), cyclin-dependent kinase inhibitor 1A (p21 |
| Alternative technique | antibodies |
| Alternative to gene target | CAP20 and CDKN1 and CIP1 and MDA-6 and P21 and p21CIP1 and SDI1 and WAF1, CDKN1A and IDBG-630156 and ENSBTAG00000008353 and 513497, CDKN1A and IDBG-85033 and ENSG00000124762 and 1026, Cdkn1a and IDBG-159848 and ENSMUSG00000023067 and 12575, Cip1), metal ion binding, nuclei, signal transduction by p53 class mediator resulting in cell cycle arrest and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009411 and response to UV and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010165 and response to X-ray and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0019912 and cyclin-dependent protein kinase activating kinase activity and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030332 and cyclin binding and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031100 and organ regeneration and biological process this GO :0031668 and cellular response to extracellular stimulus and biological process this GO :0032403 and protein complex binding and molecular function this GO :0033158 and regulation of protein import into nucleus, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0004861 and cyclin-dependent protein serine/threonine kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006977 and DNA damage response, this GO :0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity, this GO :0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity and also this GO :0005515: protein binding and also this GO :0019912: cyclin-dependent protein kinase activating kinase activity and also this GO :0030332: cyclin binding and also this GO :0032403: protein complex binding and also this GO :0046872: metal ion binding, this GO :0005515: protein binding, this GO :0019912: cyclin-dependent protein kinase activating kinase activity, this GO :0030332: cyclin binding, this GO :0032403: protein complex binding, this GO :0046872: metal ion binding, translocation and biological process this GO :0034605 and cellular response to heat and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042326 and negative regulation of phosphorylation and biological process this GO :0042493 and response to drug and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045087 and innate immune response and biological process this GO :0045736 and negative regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046685 and response to arsenic-containing substance and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051384 and response to glucocorticoid and biological process this GO :0051412 and response to corticosterone and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060574 and intestinal epithelial cell maturation and biological process this GO :0070557 and PCNA-p21 complex and cellular component this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0071850 and mitotic cell cycle arrest and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :0090398 and cellular senescence and biological process this GO :0090400 and stress-induced premature senescence and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :2000278 and regulation of DNA biosynthetic process and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process, cyclin-dependent kinase inhibitor 1A (p21 |
| Identity | 1784 |
| Gene | CDKN1A |
| Long gene name | cyclin dependent kinase inhibitor 1A |
| Synonyms gene | CDKN1 |
| Synonyms gene name | Cip1) , cyclin-dependent kinase inhibitor 1A (p21 |
| Synonyms | P21 CIP1 WAF1 SDI1 CAP20 p21CIP1 p21Cip1/Waf1 |
| Locus | 6p21, 2 |
| Discovery year | 1994-05-24 |
| GenBank acession | U03106 |
| Entrez gene record | 1026 |
| RefSeq identity | NM_078467 |
| Havana BLAST/BLAT | OTTHUMG00000014603 |
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