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CEBP-alpha Antibody

CEBP-alpha Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCEBP-alpha Primary Polyclonal Antibody
Also known asCEBP-alpha PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCEBP-alpha
Specificity Due to the similarity in amino acid composition of this protein and the closely related CEBP-beta, this antibody may be cross-react with this protein due to a 77% non-sequential sequence similarity, This is a highly specific antibody against CEBP-alpha
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range250-300/358
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CEBP-alpha
Gene ID number1050
Swiss ProtP49715
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107), Critical for the proper development of the liver and the lung (By similarity), Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, During early embryogenesis, Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP), In adipose tissue, In liver, Necessary for terminal adipocyte differentiation, Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596), Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters, To modulate lipogenesis, To regulate gluconeogenesis, To regulate these different processes at the proper moment and tissue, adipocytes, and cells of the lung and the placenta, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC, hepatocytes, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2, interplays with other transcription factors and modulators, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity), plays essential and redundant functions with CEBPB, regulates gluconeogenesis and lipogenesis through different mechanisms, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity), which is critical for its ability to induce adipocyte and granulocyte terminal differentiation, Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C/EBP alpha, C/EBP-alpha, CCAAT/enhancer-binding protein alpha, CEBPA, CEBP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCEBP-alpha
Short nameCEBP-alpha Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCEBP-a (Antibody to)
Alternative techniqueantibodies
Identity 1833
Gene CEBPA
Long gene name CCAAT/enhancer binding protein alpha
Synonyms gene CEBP
Synonyms gene name CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms C/EBP-alpha
Locus 19q13, 11
Discovery year 1991-11-27
GenBank acession M37197
Entrez gene record 1050
Pubmed identfication 1535333 1840554
RefSeq identity NM_004364
Classification CCAAT/enhancer binding proteins Basic leucine zipper proteins
Havana BLAST/BLAT OTTHUMG00000161461
Locus Specific Databases LRG_456

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