Filters

Chemerin / RARRES2 Antibody (Center Region)

Chemerin / RARRES2 Antibody (Center Region) size: 0.05 ml 199

Supplier NJS POLY
Price 199
Size 0.05 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, Antibody in 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenChemerin / RARRES2 (Center Region)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutionsWestern blot: 1:2000
Notes Titration of the Chemerin antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points
Intented useThis Chemerin antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q99969
PurityAntigen affinity
Description Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, Also acts as a proinflammatory adipokine, Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases, Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells, Exhibits an antimicrobial function in the skin, Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2), Positively regulates adipocyte differentiation, The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production, a process essential for the expansion of white adipose tissue, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues, as well as obesity- related disorders such as type 2 diabetes and cardiovascular disease, but also immature myeloid DCs, causing an increase in secretion of proinflammatory and prodiabetic adipokines, macrophages and natural killer cells, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1), modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, particularly immature plasmacytoid dendritic cells, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, Adipocyte-secreted protein (adipokine) that regulates adipogenesis
ImmunogenAmino acids 89-133 from the human protein were used as the immunogen for this Chemerin antibody
Storage Avoid repeated freeze-thaw cycles, Aliquot the Chemerin antibody and store frozen at -20oC or colder
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetChemerin / RARRES2 (Center Region)
Short nameChemerin / RARRES2 Antibody (Center Region)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameChemerin / RARRES2 (Antibody to) (central Region)
Alternative techniqueantibodies
Identity 9868
Gene RARRES2
Long gene name retinoic acid receptor responder 2
Synonyms gene name retinoic acid receptor responder (tazarotene induced) 2
Synonyms TIG2 HP10433
Synonyms name chemerin
Locus 7q36, 1
Discovery year 1998-02-03
GenBank acession U77594
Entrez gene record 5919
Pubmed identfication 9270552 17767914
Classification Endogenous ligands
Havana BLAST/BLAT OTTHUMG00000158325

Similar products

Subscribe to our Newsletter