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CHIP Antibody, Biotin Conjugated

CHIP Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, CHIP Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenCHIP
SpecificityThis is a highly specific antibody against CHIP
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range120-170/303
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human CHIP
Gene ID number10273
Swiss ProtQ9UNE7
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background 'Lys-61' and 'Lys-81', Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension, Hsc70 and Hsp90, Mediates polyubiquitination of CYP3A4, Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation, Modulates the activity of several chaperone complexes, Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223), Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation, Ubiquitinates NOS1 in concert with Hsp70 and Hsp40, including Hsp70, thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome, E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms Antigen NY-CO-7, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, E3 ubiquitin-protein ligase CHIP, HSPABP2, NY-CO-7, PP1131, SCAR16, SDCCAG7, STIP1 homology and U box-containing protein 1, STUB1, UBOX1, CHIP
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetConjugated
Short name Conjugated, CHIP Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, CHIP (Antibody to)
Alternative techniqueantibodies

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