Filters

Chk1(Checkpoint kinase 1) Antibody

Chk1(Checkpoint kinase 1) Antibody size: 0.1ml 354

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 354
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameChk1(Checkpoint kinase 1) Primary Polyclonal Antibody
Also known asChk1(Checkpoint kinase 1) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenChk1(Checkpoint kinase 1)
SpecificityThis is a highly specific antibody against Chk1(Checkpoint kinase 1)
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
SourceSynthetic peptide
Gene ID number1111
Swiss ProtO14757
Tested ApplicationsWB
Recommended dilutions000), WB (1:2
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A, 'Ser-82' and 'Ser-88' by NEK11, Also phosphorylates NEK6, Also promotes repair of DNA cross-links through phosphorylation of FANCE, Binds to and phosphorylates CDC25A, Binds to and phosphorylates RAD51 at 'Thr-309', Binds to and phosphorylates TLK1 at 'Ser-743', CDC25B and CDC25C, Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression, May also negatively regulate cell cycle progression during unperturbed cell cycles, May also play a role in replication fork maintenance through regulation of PCNA, Phosphorylates multiple sites within the C-terminus of TP53, Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C, Phosphorylation of CDC25A at 'Ser-76', Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', Recognizes the substrate consensus sequence [R-X-X-S/T], This may enhance chromatin assembly both in the presence or absence of DNA damage, This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome, thereby promoting DNA repair by homologous recombination, which is required for polyubiquitination and degradation of CDCD25A, which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation, which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CHEK1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, Serine/threonine-protein kinase Chk1, CHK1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetChk1(Checkpoint kinase 1)
Short nameChk1(Checkpoint kinase 1) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameChk1(Checkpoint phosphorylation catalyst 1) (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter