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Chk2 (Checkpoint kinase 2) (20A8) Monoclonal Antibody

Chk2 (Checkpoint kinase 2) (20A8) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameChk2 (Checkpoint kinase 2) (20A8) Monoclonal Antibody
Also known asChk2 (Checkpoint kinase 2) (20A8) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenChk2 (Checkpoint kinase 2)
SpecificityThis is a highly specific antibody against Chk2 (Checkpoint kinase 2)
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number20A8
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli(His-Chk2)
Gene ID number11200
Swiss ProtO96017
Tested Applications IP, WB
Recommended dilutions0 ug), 1 ug/mL) IP (2, WB (0
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1, Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1, CDC25B and CDC25C, Following activation, Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression, Its absence may be a cause of the chromosomal instability observed in some cancer cells, MDM4 and PML, May also negatively regulate cell cycle progression during unperturbed cell cycles, May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest, Phosphorylation of MDM4 may also reduce degradation of p53/TP53, Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978), Regulates DNA repair through phosphorylation of BRCA2, Regulates apoptosis through the phosphorylation of p53/TP53, Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, Tumor suppressor, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination, inhibiting their activity, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1, leading to accumulation of active p53/TP53, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T], Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CHEK2, CHK2, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, HuCds1, LFS2, PP1425, RAD53, Serine/threonine-protein kinase Chk2, hCds1, CDS1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetChk2 (Checkpoint kinase 2) (20A8) Monoclonal
Short nameChk2 (Checkpoint kinase 2) (20A8) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameChk2 (Checkpoint phosphorylation catalyst 2) (20A8) monoclonal (Antibody to)
Alternative techniqueantibodies

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