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CHK2 (Thr387) Antibody

CHK2 (Thr387) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCHK2 (Thr387) Primary Polyclonal Antibody
Also known asCHK2 (Thr387) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCHK2 Thr387
SpecificityThis is a highly specific antibody against CHK2 Thr387
Modification(s)Phosphorylation
Modification site(s)Thr387
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr387
Gene ID number11200
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, Indeed, Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block, Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif), The SQ/TQ cluster domain, The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, These are known to be preferred sites for phosphorylation by ATM/ATR kinases, This kinase may have a role in meiosis as well, Thr26, Thr68 and other sites in this region become phosphorylated by ATM/ATR, UV irradiation or hydroxyurea treatment, after DNA damage by ionizing radiation (IR), and may also participate in transduction of the DNA damage and replicational stress signals, preventing the entry into mitosis, seems to have a regulatory function, therefore, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain, Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CDS 1, CDS1, CHK2 checkpoint homolog, CHK2 checkpoint homolog, CHK2 checkpoint homolog S, CHK2_HUMAN, Checkpoint kinase 2, Checkpoint like protein CHK2, Chek 2, Chek2, Chk 2, HuCds 1, HuCds1, LFS 2, LFS2, PP1425, RAD 53, RAD53, Rad53 homolog, Serine/threonine protein kinase Chk2, Serine/threonine-protein kinase Chk2, pombe, bA444G7
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCHK2 (Thr387)
Short nameCHK2 (Thr387) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCHK2 (Thr387) (Antibody to)
Alternative techniqueantibodies
Identity 16627
Gene CHEK2
Long gene name checkpoint kinase 2
Synonyms gene RAD53
Synonyms gene name CHK2 (checkpoint, S, pombe) , pombe) homolog CHK2 checkpoint homolog (S
Synonyms CDS1 CHK2 HuCds1 PP1425 bA444G7
Locus 22q12, 1
Discovery year 2001-09-19
GenBank acession AF086904
Entrez gene record 11200
Pubmed identfication 9836640 10097108
RefSeq identity NM_001005735
Havana BLAST/BLAT OTTHUMG00000151023
Locus Specific Databases LRG_302

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