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CK10 Antibody

CK10 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCK10 Primary Polyclonal Antibody
Also known asCK10 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCK10
Specificity 13, 14, 15, 17 based on an 85% sequence similarity in the immunogen range, This antibody my have secondary cross-reactivities with Keratin 12, This is a highly specific antibody against CK10
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range140-190/584
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CK10
Gene ID number3858
Swiss ProtP13645
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560), AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens, At birth, Cytokeratin 10 is generally associated with keratin 1, Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum, It is seen in all suprabasal cell layers including stratum corneum, Transmission is autosomal dominant, Within a few weeks, affected individuals usually present with redness, also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq, also known as cyclic ichthyosis with epidermolytic hyperkeratosis, blisters and superficial erosions due to cytolysis, but most cases are sporadic, the erythroderma and blister formation diminish and hyperkeratoses develop, Cytokeratin 10 is a heterotetramer of two type I and two type II keratins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BCIE, CK-10, CK10, Cytokeratin-10, EHK, K10, KPP, KRT10, Keratin, Keratin-10, type I cytoskeletal 10, BIE
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCK10
Short nameCK10 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCK10 (Antibody to)
Alternative techniqueantibodies
Identity 6413
Gene KRT10
Long gene name keratin 10
Synonyms gene KPP
Synonyms gene name keratosis palmaris et plantaris keratin 10, type I
Synonyms K10 CK10
Synonyms name cytokeratin 10 epidermolytic hyperkeratosis
Locus 17q21, 2
Discovery year 1988-08-12
GenBank acession J04029
Entrez gene record 3858
Pubmed identfication 2461420 16831889
RefSeq identity NM_000421
Classification Keratins, type I
Havana BLAST/BLAT OTTHUMG00000133368

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