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CNTF Antibody / Ciliary Neurotrophic Factor

CNTF Antibody / Ciliary Neurotrophic Factor size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCNTF / Ciliary Neurotrophic Factor
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutions1-0, 1-0, 5ug/ml, 5ug/ml, ELISA : 0, Western blot: 0
NotesOptimal dilution of the CNTF antibody should be determined by the researcher
Intented useThis CNTF antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P26441
PurityAntigen affinity
Description 85% homology with the deduced aa sequence encoding human CNTF, CNTF induces weight loss and improves glucose tolerance in humans and rodents, It is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, The CNTF protein is highly conserved in evolution, The amino acid (aa) sequences of rat and rabbit CNTF translated from cDNAs display approx, This gene is located on chromosome 11, as determined using human-hamster somatic cell hybrids, in a manner similar to that of leptin, neurotransmitter synthesis and neurite outgrowth in certain neuronal populations, Ciliary neurotrophic factor (CNTF) is a potent polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes survival
ImmunogenAmino acids 12-200 of human CNTF were used as the immunogen for the CNTF antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CNTF antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCNTF / Ciliary Neurotrophic Factor
Short nameCNTF Antibody / Ciliary Neurotrophic Factor
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameciliary neurotrophic factor (Antibody to) / Ciliary Neurotrophic Factor
Alternative techniqueantibodies
Alternative to gene target CNTF and IDBG-409278 and ENSG00000242689 and 1270, CNTF and IDBG-637978 and ENSBTAG00000003624 and 100848228, Cntf and IDBG-254935 and ENSMUSG00000079415 and 12803, Extracellular, HCNTF, growth factor activity, this GO :0005127 and ciliary neurotrophic factor receptor binding and molecular function this GO :0005138 and interleukin-6 receptor binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007165 and signal transduction and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0040007 and growth and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0046533 and negative regulation of photoreceptor cell differentiation and biological process this GO :0046668 and regulation of retinal cell programmed cell death and biological process this GO :0048644 and muscle organ morphogenesis and biological process this GO :0048666 and neuron development and biological process this GO :0070120 and ciliary neurotrophic factor-mediated signaling pathway and biological process this GO :0097058 and CRLF-CLCF1 complex and cellular component, this GO :0005127: ciliary neurotrophic factor receptor binding, this GO :0005127: ciliary neurotrophic factor receptor binding and also this GO :0005138: interleukin-6 receptor binding and also this GO :0008083: growth factor activity, this GO :0005138: interleukin-6 receptor binding, this GO :0008083: growth factor activity, ciliary neurotrophic factor
Identity 2169
Gene CNTF
Long gene name ciliary neurotrophic factor
Synonyms HCNTF
Locus 11q12, 1
Discovery year 1991-01-07
GenBank acession BC068030
Entrez gene record 1270
Pubmed identfication 1840538 1714745
RefSeq identity NM_000614
Classification Interleukin 6 cytokine family
Havana BLAST/BLAT OTTHUMG00000137476
Locus Specific Databases ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

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