| Long name | 37) Monoclonal Antibody, 53, CSF1R (1486CT328 |
| Also known as | 37) Monoclonal Antibody, 53, CSF1R (1486CT328 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CSF1R |
| Specificity | This is a highly specific antibody against CSF1R |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1486CT328, 37, 53 |
| Source | This CSF1R antibody is generated from a mouse immunized with a recombinant protein |
| Gene ID number | 1436 |
| Swiss Prot | P07333 |
| Tested Applications | IHC-P, WB |
| Recommended dilutions | WB(1-500-2000), IHC-P(1:25) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, Activates several signaling pathways in response to ligand binding, Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FYN and YES1, GRB2, PLCG2, Phosphorylates PIK3R1, Phosphorylation of PIK3R1, Plays an important role in the regulation of osteoclast proliferation and differentiation, Promotes activation of STAT family members STAT3, Promotes reorganization of the actin cytoskeleton, Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1, Required for normal male and female fertility, SLA2 and CBL, STAT5A and/or STAT5B, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy, and is required for normal bone and tooth development, and of the SRC family kinases SRC, and promotes cancer cell invasion, and thereby plays an important role in innate immunity and in inflammatory processes, cell adhesion and cell migration, especially PRKCD, especially mononuclear phagocytes, leads to activation of the AKT1 signaling pathway, or via adapter proteins, proliferation and differentiation of hematopoietic precursor cells, regulates formation of membrane ruffles, such as GRB2, such as macrophages and monocytes, that then lead to the activation of protein kinase C family members, the regulation of bone resorption, the regulatory subunit of phosphatidylinositol 3-kinase, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival |
| Purification method | Purified by Protein G |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | C-FMS, CD115, CSF-1 receptor, CSF-1-R, CSF-1R, CSF1R, CSFR, FIM2, HDLS, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, Proto-oncogene c-Fms, FMS |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 37) Monoclonal, 53, CSF1R (1486CT328 |
| Short name | 37) Monoclonal Antibody, 53, CSF1R (1486CT328 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 37) monoclonal (Antibody to), 53, colony stimulating factor 1 receptor (1486CT328 |
| Alternative technique | antibodies |
| Alternative to gene target | C-FMS and CD115 and CSF-1R and CSFR and FIM2 and FMS and HDLS and M-CSF-R, CSF1R and IDBG-53268 and ENSG00000182578 and 1436, CSF1R and IDBG-646265 and ENSBTAG00000012771 and 509418, Cell surfaces, Csf1r and IDBG-150998 and ENSMUSG00000024621 and 12978, this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005011 and macrophage colony-stimulating factor receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004714: transmembrane receptor protein tyrosine kinase activity and also this GO :0005011: macrophage colony-stimulating factor receptor activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004714: transmembrane receptor protein tyrosine kinase activity, this GO :0005011: macrophage colony-stimulating factor receptor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019903: protein phosphatase binding, this GO :0019955: cytokine binding, this GO :0042803: protein homodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019903: protein phosphatase binding and also this GO :0019955: cytokine binding and also this GO :0042803: protein homodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019903 and protein phosphatase binding and molecular function this GO :0019955 and cytokine binding and molecular function this GO :0030097 and hemopoiesis and biological process this GO :0030224 and monocyte differentiation and biological process this GO :0030225 and macrophage differentiation and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0031529 and ruffle organization and biological process this GO :0036006 and cellular response to macrophage colony-stimulating factor stimulus and biological process this GO :0038145 and macrophage colony-stimulating factor signaling pathway and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043235 and receptor complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045217 and cell-cell junction maintenance and biological process this GO :0046488 and phosphatidylinositol metabolic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090197 and positive regulation of chemokine secretion and biological process this GO :2000147 and positive regulation of cell motility and biological process this GO :2000249 and regulation of actin cytoskeleton reorganization and biological process, colony stimulating factor 1 receptor |
| Identity | 2433 |
| Gene | CSF1R |
| Long gene name | colony stimulating factor 1 receptor |
| Synonyms gene | FMS |
| Synonyms gene name | McDonough feline sarcoma viral (v-fms) oncogene homolog |
| Synonyms | C-FMS CSFR CD115 |
| Locus | 5q32 |
| Discovery year | 2001-06-22 |
| GenBank acession | U63963 |
| Entrez gene record | 1436 |
| Pubmed identfication | 1611909 |
| RefSeq identity | NM_005211 |
| Classification | Immunoglobulin like domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT | OTTHUMG00000130050 |
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