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CTCF Antibody

CTCF Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCTCF Primary Polyclonal Antibody
Also known asCTCF PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCTCF
SpecificityThis is a highly specific antibody against CTCF
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range470-520/727
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CTCF
Gene ID number10664
Swiss ProtP49711
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a transcriptional activator of APP, Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene, Also binds to the PLK and PIM1 promoters, Can dimerize when it is bound to different DNA sequences, Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, Inversely, Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers, May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation, Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory, On the maternal allele, Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus, Plays a critical role in gene silencing over considerable distances in the genome, Plays a critical role in the epigenetic regulation, Plays a important role in chromatin remodeling, Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription, Preferentially interacts with unmethylated DNA, Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression, Seems to act as tumor suppressor, Seems to be essential for homologous X-chromosome pairing, When bound to chromatin, binding to target sites is prevented by CpG methylation, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2, it provides an anchor point for nucleosomes positioning, mediating long-range chromatin looping, preventing spreading of CpG methylation and maintaining methylation-free zones, without affecting transcription, Chromatin binding factor that binds to DNA sequence specific sites
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 11-zinc finger protein, CCCTC-binding factor, CTCF, CTCFL paralog, Transcriptional repressor CTCF, MRD21
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCTCF
Short nameCTCF Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCTCF (Antibody to)
Alternative techniqueantibodies
Identity 13723
Gene CTCF
Long gene name CCCTC-binding factor
Synonyms gene name CCCTC-binding factor (zinc finger protein)
Synonyms name 11 zinc finger transcriptional repressor
Locus 16q22, 1
Discovery year 2000-10-20
GenBank acession U25435
Entrez gene record 10664
Pubmed identfication 8649389 18550811
RefSeq identity NM_006565
Classification Zinc fingers C2H2-type
Havana BLAST/BLAT OTTHUMG00000137539

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