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Cullin 3 Antibody

Cullin 3 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCullin 3 Primary Polyclonal Antibody
Also known asCullin 3 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCullin 3
Specificity This antibody may detect Cullin-4 A/B, This is a highly specific antibody against Cullin 3
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range430-480/768
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cullin 3
Gene ID number8452
Swiss ProtQ13618
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, BCR(KLHL42) is involved in ubiquitination of KATNA1, BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis, BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, GLI2 and GLI3, H2AFY and DAXX, PubMed:21670212, PubMed:21840486, PubMed:24768539), The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity), The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component, by mediating ubiquitination of WNK4, thereby playing a key role in collagen export, these complexes have lower ubiquitin ligase activity, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B), Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CUL3, Cullin-3, KIAA0617, PHA2E, CUL-3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCullin 3
Short nameCullin 3 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCullin 3 (Antibody to)
Alternative techniqueantibodies
Identity 2553
Gene CUL3
Long gene name cullin 3
Locus 2q36, 2
Discovery year 1998-10-29
GenBank acession U58089
Entrez gene record 8452
Pubmed identfication 8681378 17192413
Classification Cullins
Havana BLAST/BLAT OTTHUMG00000133167

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