| Long name | CXCR4 Primary Polyclonal Antibody |
| Also known as | CXCR4 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CXCR4 |
| Specificity | This is a highly specific antibody against CXCR4 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 217-241/352 |
| Subcellular location | Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CXCR4 |
| Gene ID number | 7852 |
| Tested Applications | FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions | FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates, Acts as a receptor for extracellular ubiquitin, Also plays an essential role in vascularization of the gastrointestinal tract, Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, In the CNS, Involved in cerebellar development, Involved in hematopoiesis and in cardiac ventricular septum formation, Promotes Env-mediated fusion of the virus, could mediate hippocampal-neuron survival, including TNF secretion by monocytes, leading to enhanced intracellular calcium ions and reduced cellular cAMP levels, probably by regulating vascular branching and/or remodeling processes in endothelial cells, Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CD184, CXC-R4, CXCR-4, CXCR4, FB22, Fusin, HM89, LAP-3, LCR1, LESTR, LPS-associated protein 3, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide-associated protein 3, NPYRL, SDF-1 receptor, Stromal cell-derived factor 1 receptor, C-X-C chemokine receptor type 4 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | CXCR4 |
| Short name | CXCR4 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | chemokine (C-X-C motif) receptor 4 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | CD184 and D2S201E and FB22 and HM89 and HSY3RR and LAP-3 and LAP3 and LCR1 and LESTR and NPY3R and NPYR and NPYRL and NPYY3R and WHIM, CXCR4 and IDBG-642187 and ENSBTAG00000001060 and 281736, CXCR4 and IDBG-71032 and ENSG00000121966 and 7852, Cell surfaces, Cxcr4 and IDBG-189999 and ENSMUSG00000045382 and 12767, this GO :0000187 and activation of MAPK activity and biological process this GO :0001569 and patterning of blood vessels and biological process this GO :0001618 and virus receptor activity and molecular function this GO :0001666 and response to hypoxia and biological process this GO :0001667 and ameboidal cell migration and biological process this GO :0001764 and neuron migration and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0003779 and actin binding and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007281 and germ cell development and biological process this GO :0007420 and brain development and biological process this GO :0008045 and motor neuron axon guidance and biological process this GO :0008354 and germ cell migration and biological process this GO :0009615 and response to virus and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016032 and viral process and biological process this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0019722 and calcium-mediated signaling and biological process this GO :0019955 and cytokine binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0030260 and entry into host cell and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0030426 and growth cone and cellular component this GO :0031252 and cell leading edge and cellular component this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032027 and myosin light chain binding and molecular function this GO :0042098 and T cell proliferation and biological process this GO :0042119 and neutrophil activation and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0043217 and myelin maintenance and biological process this GO :0045087 and innate immune response and biological process this GO :0048699 and generation of neurons and biological process this GO :0048714 and positive regulation of oli this GO dendrocyte differentiation and biological process this GO :0050920 and regulation of chemotaxis and biological process this GO :0061351 and neural precursor cell proliferation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process, this GO :0001618: virus receptor activity, this GO :0001618: virus receptor activity and also this GO :0003779: actin binding and also this GO :0004930: G-protein coupled receptor activity and also this GO :0005515: protein binding and also this GO :0015026: coreceptor activity and also this GO :0016494: C-X-C chemokine receptor activity and also this GO :0019955: cytokine binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0032027: myosin light chain binding and also this GO :0043130: ubiquitin binding, this GO :0003779: actin binding, this GO :0004930: G-protein coupled receptor activity, this GO :0005515: protein binding, this GO :0015026: coreceptor activity, this GO :0016494: C-X-C chemokine receptor activity, this GO :0019955: cytokine binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0032027: myosin light chain binding, this GO :0043130: ubiquitin binding, ubiquitin binding, chemokine (C-X-C motif) receptor 4 |
| Identity | 2561 |
| Gene | CXCR4 |
| Long gene name | C-X-C motif chemokine receptor 4 |
| Synonyms gene name | chemokine (C-X-C motif), receptor 4 (fusin) chemokine (C-X-C motif) receptor 4 |
| Synonyms | LESTR NPY3R HM89 NPYY3R D2S201E fusin HSY3RR NPYR CD184 |
| Locus | 2q22, 1 |
| Discovery year | 1998-09-17 |
| GenBank acession | AF005058 |
| Entrez gene record | 7852 |
| Pubmed identfication | 9599023 9379028 |
| Classification | CD molecules C-X-C motif chemokine receptors |
| Havana BLAST/BLAT | OTTHUMG00000153583 |
| Locus Specific Databases | CXCR4base: Mutation registry for WHIM syndrome (warts, and myelokathexis) LRG_51 , hypogammaglobulinemia, immunodeficiency |
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