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Cyclin D1 Antibody

Cyclin D1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCyclin D1 Primary Polyclonal Antibody
Also known asCyclin D1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCyclin D1
SpecificityThis is a highly specific antibody against Cyclin D1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range70-120/295
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from mouse Cyclin D1
Gene ID number12443
Swiss ProtP25322
Tested Applications FCM, IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Goat, Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also substrate for SMAD3, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity), Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D1/CDK4/CDKN1B, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AI32739, Ccnd1, CycD1, Cyl-1, G1/S-specific cyclin-D1, PRAD1, bcl-1, cD1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCyclin D1
Short nameCyclin D1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCyclin D1 (Antibody to)
Alternative techniqueantibodies
Identity 1582
Gene CCND1
Long gene name cyclin D1
Synonyms gene BCL1 D11S287E PRAD1
Synonyms gene name cyclin D1 (PRAD1: parathyroid adenomatosis 1)
Synonyms U21B31
Synonyms name parathyroid adenomatosis 1 B-cell CLL/lymphoma 1 G1/S-specific cyclin D1
Locus 11q13, 3
Discovery year 1991-06-06
GenBank acession Z23022
Entrez gene record 595
Pubmed identfication 1826542 1833066
RefSeq identity NM_053056
Classification Cyclins
Havana BLAST/BLAT OTTHUMG00000167877
Locus Specific Databases LRG_990

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