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Cyclin D1 Antibody, ALEXA FLUOR 488

Cyclin D1 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, Cyclin D1 Polyclonal Antibody
Also known asAnti-Cyclin D1 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenCyclin D1
SpecificityThis is a highly specific antibody against Cyclin D1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range70-120/295
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from mouse Cyclin D1
Gene ID Number12443
Swiss ProtP25322
Tested applications IF(ICC), IF(IHC-P), FCM
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Goat, Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Also substrate for SMAD3, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity), Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D1/CDK4/CDKN1B, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms U21B31
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Cyclin D1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetCyclin D1
Short nameCyclin D1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, Cyclin D1 (Antibody to)
Alternative techniqueantibodies
Identity 1582
Gene CCND1
Long gene name cyclin D1
Synonyms gene BCL1 D11S287E PRAD1
Synonyms gene name cyclin D1 (PRAD1: parathyroid adenomatosis 1)
Synonyms name parathyroid adenomatosis 1 B-cell CLL/lymphoma 1 G1/S-specific cyclin D1
Locus 11q13, 3
Discovery year 1991-06-06
GenBank acession Z23022
Entrez gene record 595
Pubmed identfication 1826542 1833066
RefSeq identity NM_053056
Classification Cyclins
Havana BLAST/BLAT OTTHUMG00000167877
Locus Specific Databases LRG_990

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