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Cyclin D2 Antibody

Cyclin D2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCyclin D2 Primary Polyclonal Antibody
Also known asCyclin D2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCyclin D2
SpecificityThis is a highly specific antibody against Cyclin D2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range150-200/288
Subcellular location Membrane bound, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cyclin D2
Gene ID number894
Swiss ProtP30279
Tested Applications IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also substrate for SMAD3, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D2/CDK4/CDKN1B, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity), Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CCND2, G1/S-specific cyclin-D2, KIAK2, MPPH3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCyclin D2
Short nameCyclin D2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCyclin D2 (Antibody to)
Alternative techniqueantibodies
Identity 1583
Gene CCND2
Long gene name cyclin D2
Synonyms name G1/S-specific cyclin D2
Locus 12p13, 32
Discovery year 1991-12-10
GenBank acession AF518005
Entrez gene record 894
Pubmed identfication 1386335
RefSeq identity NM_001759
Classification Cyclins
Havana BLAST/BLAT OTTHUMG00000168123

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