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Cyclin D3 Antibody (CCND3)

Cyclin D3 Antibody (CCND3) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCyclin D3 (CCND3)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:1000
NotesTitration of the CCND3 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis CCND3 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P30281
PurityAntigen affinity
Description Also substrate for SMAD3, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D3/CDK4/CDKN1B, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition
ImmunogenA portion of amino acids 252-281 from the human protein was used as the immunogen for this CCND3 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CCND3 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCyclin D3 (CCND3)
Short nameCyclin D3 Antibody (CCND3)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCyclin D3 (Antibody to) (cyclin D3)
Alternative techniqueantibodies
Alternative to gene target BT, CCND3 and IDBG-86973 and ENSG00000112576 and 896, Ccnd3 and IDBG-189288 and ENSMUSG00000034165 and 12445, nuclei, protein kinase binding, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004693 and cyclin-dependent protein serine/threonine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007049 and cell cycle and biological process this GO :0007165 and signal transduction and biological process this GO :0016020 and membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0042098 and T cell proliferation and biological process this GO :0045737 and positive regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0051301 and cell division and biological process this GO :0051726 and regulation of cell cycle and biological process, this GO :0004693: cyclin-dependent protein serine/threonine kinase activity, this GO :0004693: cyclin-dependent protein serine/threonine kinase activity and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding, this GO :0005515: protein binding, this GO :0019901: protein kinase binding, 29057 and IDBG-631016 and ENSBTAG00000010106 and 540547, cyclin D3
Identity 1585
Gene CCND3
Long gene name cyclin D3
Locus 6p21, 1
Discovery year 1991-12-10
Entrez gene record 896
Pubmed identfication 1386335
RefSeq identity NM_001760
Classification Cyclins
Havana BLAST/BLAT OTTHUMG00000014690
Locus Specific Databases LRG_998

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