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Cytohesin 2 Antibody

Cytohesin 2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCytohesin 2 Primary Polyclonal Antibody
Also known asCytohesin 2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCytohesin 2
SpecificityThis is a highly specific antibody against Cytohesin 2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cytohesin 2
Gene ID number9266
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), All GEFs have a highly conserved Sec7 domain, All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain, Arf has a number of disparate activities including maintenance of organelle integrity, Arf is found to be active when bound to GTP and inactive when bound to GDP, Arf is involved in intracellular protein traffic to and within the Golgi complex, Arfâ, GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA), Like other small GTPases, Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation, The PH domain has been shown to interact with phosphatidylinositol 3, This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase), and cytohesin-4, as a co-factor for cholera toxin and as an activator of phospholipase D, assembly of coat proteins, cytohesin-2 (ARNO), cytohesin-3 (ARNO3), which are members of the Ras superfamily of regulatory GTP-binding proteins, &euro, &trade, 4, 5-triphosphate and is believed to promote membrane targeting of the cytohesins, The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ARF nucleotide binding site opener, ARNO protein, Arno, CLM2, CTS18, CTS18, CYH2_HUMAN, Cyth2, Cytohesin 2, MGC137537, MGC80440, PH, PSCD2, PSCD2L, PSCD2L, Pleckstrin homology Sec7 and coiled coil domains 2, Pleckstrin homology Sec7 and coiled coil domains protein 2, SEC7 and coiled-coil domain-containing protein 2, SEC7 homolog B, SEC7L, Sec7, Sec7B, Sec7p L, Sec7p-like, Sec7pL, formerly, 1, ARF exchange factor
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCytohesin 2
Short nameCytohesin 2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCytohesin 2 (Antibody to)
Alternative techniqueantibodies
Identity 9503
Gene PSCD2L
Long gene name cytohesin 2
Synonyms gene PSCD2
Synonyms gene name Sec7 and coiled-coil domains 2 , Sec7 and coiled/coil domains 2 (cytohesin-2) pleckstrin homology, pleckstrin homology
Synonyms CTS18, 1 Sec7p-L ARNO Sec7p-like cytohesin-2 CYTH2
Locus 19q13, 33
Discovery year 1998-11-19
GenBank acession X99753
Entrez gene record 9266
Pubmed identfication 8706128 8945478 20525696
RefSeq identity NM_004228
Classification Pleckstrin homology domain containing
Havana BLAST/BLAT OTTHUMG00000150245

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