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Dab1 (Tyr220) Antibody, ALEXA FLUOR 555

Dab1 (Tyr220) Antibody, ALEXA FLUOR 555 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, Dab1 (Tyr220) Polyclonal Antibody
Also known asAnti-Dab1 Tyr220 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenDab1 Tyr220
SpecificityThis is a highly specific antibody against Dab1 Tyr220
ModificationPhosphorylation
Modification SiteTyr220
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr220
Gene ID Number1600
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus, Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin, Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, Phenotypically, Reelin-induced signaling during neural cortex development, Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1, Tau, Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases, and severe cerebellar hypoplasia, disruption of neuronal migration, likely indirectly, the mutation of this gene produces motor defects and ataxia, Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms Disabled homolog 1, Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari, Dab 1
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetDab1 (Tyr220)
Short nameDab1 (Tyr220) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, disabled homolog 1 (Drosophila) (Tyr220) (Antibody to)
Alternative techniqueantibodies

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