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DAB2 (Ser24) Antibody, Biotin Conjugated

DAB2 (Ser24) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, DAB2 (Ser24) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenDAB2 Ser24
SpecificityThis is a highly specific antibody against DAB2 Ser24
ModificationPhosphorylation
Modification siteSer24
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP(p-S)KK]
Gene ID number1601
Swiss ProtP98082
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Can bind and assemble clathrin, Can function in clathrin-mediated endocytosis independently of the AP-2 complex, EPS15L1 and ITSN1, Involved in CFTR trafficking to the late endosome, Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2, Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR, Involved in endocytosis of integrin beta-1, Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development, Involved in several receptor-mediated signaling pathways, May activate non-canonical Wnt signaling, May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1), Mediates TFG-beta-stimulated JNK activation, Required for recycling of the TGF-beta receptor, Sequesters LRP6 towards clathrin-mediated endocytosis, and binds simultaneously to phosphatidylinositol 4, leading to inhibition of Wnt/beta-catenin signaling, such as the LDL receptor, this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, to recruit them to clathrin-coated pits, 5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, 5-bisphosphate (PtdIns(4, Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms DOC-2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetDAB2 (Ser24) Conjugated
Short name Conjugated, DAB2 (Ser24) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, DAB2 (Ser24) (Antibody to)
Alternative techniqueantibodies
Identity 2662
Gene DAB2
Long gene name DAB2, clathrin adaptor protein
Synonyms gene name disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) disabled homolog 2, homolog 2 (Drosophila) , mitogen-responsive phosphoprotein, mitogen-responsive phosphoprotein (Drosophila) Dab
Locus 5p13, 1
Discovery year 1998-07-29
GenBank acession U53446
Entrez gene record 1601
Pubmed identfication 8660969 9620555
RefSeq identity NM_001343
Havana BLAST/BLAT OTTHUMG00000162043

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