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DC-SIGNR/CD299 Antibody, Biotin Conjugated

DC-SIGNR/CD299 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, DC-SIGNR/CD299 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenDC-SIGNR/CD299
SpecificityThis is a highly specific antibody against DC-SIGNR/CD299
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human CD299
Gene ID number10332
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A key molecule, CD209L, CD299 is located on Human chromosome 19p13, CD299 is polymorphic, CD299 is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC, DC SIGN2, Efforts to identify additional type II membrane proteins resulted in the isolation of a related molecule named CD299, Expression of CD299 is restricted to endothelial cells derived from liver sinusoids, Its structure is similar to DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion, This is further supported by a study demonstrating the ability to isolate a large repertoire of CD299 transcripts largely the result of alternative splicing of the 7 coding exons, also known as DC SIGNR (DC SIGN Related), although variable expression in placenta and some monocytic cell lines has also been reported, and L SIGN (liver/lymph nodespecific ICAM3 grabbing nonintegrin), and capillaries, dendritic cell specific ICAM3 grabbing nonintegrin (DC SIGN1), including ICAM3 and HIV 1 gp120, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV 1, including both membrane and soluble isoforms of the protein, is involved in regulating interactions between DC and resting T cells, lymph nodes sinuses, since allelic variations of the exon 4 encoded sequence have been isolated, 3 and shares 73-80% amino acid identity with DC SIGN1, Dendritic cells (DC) play a primary role in the immune system as antigen presenting cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms HP10347 DC-SIGNR LSIGN DCSIGNR DC-SIGN2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetDC-SIGNR/CD299 Conjugated
Short name Conjugated, DC-SIGNR/CD299 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, DC-SIGNR/CD299 (Antibody to)
Alternative techniqueantibodies
Identity 13523
Gene CLEC4M
Long gene name C-type lectin domain family 4 member M
Synonyms gene CD209L CD299
Synonyms gene name CD299 antigen C-type lectin domain family 4, member M
Locus 19p13, 2
Discovery year 2000-09-19
GenBank acession AB015629
Entrez gene record 10332
Pubmed identfication 10072769
RefSeq identity NM_014257
Classification CD molecules C-type lectin domain family
Havana BLAST/BLAT OTTHUMG00000182432

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