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DC-SIGNR/CD299 Antibody, Cy7 Conjugated

DC-SIGNR/CD299 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, DC-SIGNR/CD299 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenDC-SIGNR/CD299
SpecificityThis is a highly specific antibody against DC-SIGNR/CD299
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human CD299
Gene ID number10332
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A key molecule, CD209L, CD299 is located on Human chromosome 19p13, CD299 is polymorphic, CD299 is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC, DC SIGN2, Efforts to identify additional type II membrane proteins resulted in the isolation of a related molecule named CD299, Expression of CD299 is restricted to endothelial cells derived from liver sinusoids, Its structure is similar to DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion, This is further supported by a study demonstrating the ability to isolate a large repertoire of CD299 transcripts largely the result of alternative splicing of the 7 coding exons, also known as DC SIGNR (DC SIGN Related), although variable expression in placenta and some monocytic cell lines has also been reported, and L SIGN (liver/lymph nodespecific ICAM3 grabbing nonintegrin), and capillaries, dendritic cell specific ICAM3 grabbing nonintegrin (DC SIGN1), including ICAM3 and HIV 1 gp120, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV 1, including both membrane and soluble isoforms of the protein, is involved in regulating interactions between DC and resting T cells, lymph nodes sinuses, since allelic variations of the exon 4 encoded sequence have been isolated, 3 and shares 73-80% amino acid identity with DC SIGN1, Dendritic cells (DC) play a primary role in the immune system as antigen presenting cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms HP10347 DC-SIGNR LSIGN DCSIGNR DC-SIGN2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetDC-SIGNR/CD299 Conjugated
Short name Conjugated, DC-SIGNR/CD299 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, DC-SIGNR/CD299 (Antibody to)
Alternative techniqueantibodies
Identity 13523
Gene CLEC4M
Long gene name C-type lectin domain family 4 member M
Synonyms gene CD209L CD299
Synonyms gene name CD299 antigen C-type lectin domain family 4, member M
Locus 19p13, 2
Discovery year 2000-09-19
GenBank acession AB015629
Entrez gene record 10332
Pubmed identfication 10072769
RefSeq identity NM_014257
Classification CD molecules C-type lectin domain family
Havana BLAST/BLAT OTTHUMG00000182432

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