DCTN1 Antibody

DCTN1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	DCTN1 Primary Polyclonal Antibody
Also known as	DCTN1 PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	DCTN1
Specificity	This is a highly specific antibody against DCTN1
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1
Gene ID number	1639
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	ALS is a neurodegenerative disorder affecting upper and lower motor neurons, Brain, Death usually occurs within 2 to 5 years, Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B), Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles, HMN7B is a neuromuscular disorder, Later on, Parkinsonism develops later and respiratory failure occurred terminally, Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, Sensory abnormalities are absent, The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs, The etiology is likely to be multifactorial, The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss, also called parkinsonism with alveolar hypoventilation and mental depression, also known as progressive lower motor neuron disease (PLMND), and resulting in fatal paralysis, exhaustion and marked weight loss, involving both genetic and environmental factors, sleep disturbances, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs, without sensory deficit in the posterior horn, Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS), Defects in DCTN1 are the cause of Perry syndrome (PERRYS), Involvement in disease, Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules, Tissue specificity
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	150 kDa dynein-associated polypeptide, DAP 150, DAP-150, DAP150, DCTN 1, DCTN1, DCTN1_HUMAN, DP 150, DP-150, DP150, Dynactin 1, Dynactin 1 p150 Glued Drosophila homolog, Dynactin 1 p150 glued homolog Drosophila, Dynactin subunit 1, Dynactin1, HMN7B, P135, p150 Glued Drosophila homolog, p150 glued, p150 glued homolog, p150-glued, p150GLUED DROSOPHILA HOMOLOG OF, p150glued, Alternative names150 kDa dynein associated polypeptide
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	DCTN1
Short name	DCTN1 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	DCTN1 (Antibody to)
Alternative technique	antibodies
Identity	2711
Gene	DCTN1
Long gene name	dynactin subunit 1
Synonyms gene name	Glued (Drosophila) homolog) , dynactin 1 (p150
Synonyms name	p150 glued homolog (Drosophila)
Locus	2p13, 1
Discovery year	1995-10-03
Entrez gene record	1639
Pubmed identfication	1828535
RefSeq identity	NM_004082
Classification	Dynactin
Havana BLAST/BLAT	OTTHUMG00000129963
Locus Specific Databases	Inherited Peripheral Neuropathies Mutation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_237

DCTN1 Antibody

DCTN1 Antibody size: 0.1ml 263

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