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DDB2 Antibody

DDB2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDDB2 Primary Polyclonal Antibody
Also known asDDB2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDDB2
Specificity This antibody may have a minor secondary cross-reactivity to TNFAIP3-interacting protein 2 due to a 63% non-sequential sequence similarity in the immunogen region, This is a highly specific antibody against DDB2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range230-270/427
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DDB2
Gene ID number1643
Swiss ProtQ92466
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen 6-4 photoproducts (6-4 PP), Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex), Isoform D1 and isoform D2 inhibit UV-damaged DNA repair, The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair, The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair, apurinic sites and short mismatches, histone H3 and histone H4 at sites of UV-induced DNA damage, which may enhance DNA-binding by XPC and promote NER, Required for DNA repair
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DDB p48 subunit, DDB2, DNA damage-binding protein 2, Damage-specific DNA-binding protein 2, UV-DDB 2, UV-DDB2, UV-damaged DNA-binding protein 2, DDBB
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDDB2
Short nameDDB2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDDB2 (Antibody to)
Alternative techniqueantibodies
Identity 2718
Gene DDB2
Long gene name damage specific DNA binding protein 2
Synonyms gene name damage-specific DNA binding protein 2 (48kD)
Synonyms DDBB UV-DDB2 FLJ34321 XPE
Synonyms name xeroderma pigmentosum group E protein UV-damaged DNA-binding protein 2 DDB p48 subunit
Locus 11p11, 2
Discovery year 1995-07-06
Entrez gene record 1643
Pubmed identfication 8407967 8530102
RefSeq identity NM_000107
Classification Xeroderma pigmentosum complementation groups Nucleotide excision repair WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000187453
Locus Specific Databases LRG_467

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