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DEDD2 Antibody, FITC Conjugated

DEDD2 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, DEDD2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenDEDD2
SpecificityThis is a highly specific antibody against DEDD2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human DEDD2
Gene ID number162989
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A novel death effector domain (DED)-containing protein, At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2, DEDD2, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, Like the related protein DEDD, More recently, Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis, has been recently identified, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD, Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms FLAME-3
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetDEDD2 Conjugated
Short name FITC Conjugated, DEDD2 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, death effector domain containing 2 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target DEDD2 and IDBG-53904 and ENSG00000160570 and 162989, DEDD2 and IDBG-638613 and ENSBTAG00000005761 and 534251, DNA-templated and biological process this GO :0006396 and RNA processing and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016075 and rRNA catabolic process and biological process this GO :0019725 and cellular homeostasis and biological process this GO :0030159 and receptor signaling complex scaffold activity and molecular function this GO :0030262 and apoptotic nuclear changes and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, Dedd2 and IDBG-156541 and ENSMUSG00000054499 and 67379, nuclei, receptor signaling complex scaffold activity, this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005730 and nucleolus and cellular component this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0005515: protein binding and also this GO :0030159: receptor signaling complex scaffold activity, this GO :0005515: protein binding, this GO :0030159: receptor signaling complex scaffold activity, death effector domain containing 2
Identity 24450
Gene DEDD2
Long gene name death effector domain containing 2
Locus 19q13, 2
Discovery year 2004-02-10
GenBank acession AY125488
Entrez gene record 162989
Pubmed identfication 11965497 12235123
RefSeq identity NM_133328
Classification Death effector domain containing
Havana BLAST/BLAT OTTHUMG00000182763

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