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DJ-1 (PARK7) (1D7) Monoclonal Antibody

DJ-1 (PARK7) (1D7) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDJ-1 (PARK7) (1D7) Monoclonal Antibody
Also known asDJ-1 (PARK7) (1D7) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDJ-1 (PARK7)
SpecificityThis is a highly specific antibody against DJ-1 (PARK7)
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1D7
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli (HIS-DJ-1)
Gene ID number11315
Swiss ProtQ99497
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions0ug/ml), WB (1
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts on early glycation intermediates (hemithioacetals and aminocarbinols), Deglycates cysteines, Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825), It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, Its involvement in protein repair could also explain other unrelated functions, Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745), Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease, PubMed:12796482, PubMed:14749723, PubMed:15502874, PubMed:16632486), PubMed:17015834, PubMed:18711745, PubMed:18711745), PubMed:19229105, PubMed:20304780, PubMed:21097510, PubMed:25416785), Regulates astrocyte inflammatory responses, Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, and releases repaired proteins and lactate or glycolate, and thus reactivates these proteins by reversing glycation by glyoxals, arginines and lysines residues in proteins, for instance, functions probably related to its primary function (PubMed:17015834, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785), respectively, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DJ-1, HEL-S-67p, Oncogene DJ1, PARK7, Parkinson disease protein 7, Protein deglycase DJ-1, DJ1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetDJ-1 (PARK7) (1D7) Monoclonal
Short nameDJ-1 (PARK7) (1D7) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameDJ-1 (PARK7) (1D7) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 16369
Gene PARK7
Long gene name Parkinsonism associated deglycase
Synonyms gene name Parkinson disease (autosomal recessive, early onset) 7 parkinson protein 7
Synonyms DJ-1 DJ1
Locus 1p36, 23
Discovery year 2001-08-07
GenBank acession D61380
Entrez gene record 11315
Pubmed identfication 11462174 9070310 25416785
RefSeq identity NM_007262
Classification Parkinson disease associated genes
Havana BLAST/BLAT OTTHUMG00000001210
Locus Specific Databases Parkinson', s disease Mutation Database

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