| Long name | DLC1 Primary Polyclonal Antibody |
| Also known as | DLC1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | DLC1 |
| Specificity | This is a highly specific antibody against DLC1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 35-65/89 |
| Subcellular location | Mitochondrion, Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DLC1 |
| Gene ID number | 8655 |
| Swiss Prot | P63167 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Binds and inhibits the catalytic activity of neuronal nitric oxide synthase, Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules, May play a role in changing or maintaining the spatial distribution of cytoskeletal structures, Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1, Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules, Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity, Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | 8 kDa dynein light chain, DLC1, DLC8, DNCL1, DNCLC1, DYNLL1, Dynein light chain 1, Dynein light chain LC8-type 1, LC8a, PIN, Protein inhibitor of neuronal nitric oxide synthase, cytoplasmic, hdlc1, LC8 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | DLC1 |
| Short name | DLC1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | deleted in liver cancer 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | ARHGAP7 and HP and p122-RhoGAP and STARD12, BT, DLC1 and IDBG-7954 and ENSG00000164741 and 10395, Dlc1 and IDBG-149173 and ENSMUSG00000031523 and 50768, SH2 domain binding, nuclei, this GO :0001843 and neural tube closure and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0005100 and Rho GTPase activator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005901 and caveola and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008289 and lipid binding and molecular function this GO :0008360 and regulation of cell shape and biological process this GO :0021575 and hindbrain morphogenesis and biological process this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030900 and forebrain development and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0032956 and regulation of actin cytoskeleton organization and biological process this GO :0035024 and negative regulation of Rho protein signal transduction and biological process this GO :0035307 and positive regulation of protein dephosphorylation and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0048041 and focal adhesion assembly and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0051497 and negative regulation of stress fiber assembly and biological process this GO :1900119 and positive regulation of execution phase of apoptosis and biological process, this GO :0005100: Rho GTPase activator activity, this GO :0005100: Rho GTPase activator activity and also this GO :0005515: protein binding and also this GO :0008289: lipid binding and also this GO :0042169: SH2 domain binding, this GO :0005515: protein binding, this GO :0008289: lipid binding, this GO :0042169: SH2 domain binding, 24236 and IDBG-628726 and ENSBTAG00000015541 and 511433, deleted in liver cancer 1 |
| Identity | 2899 |
| Gene | DLEC1 |
| Long gene name | deleted in lung and esophageal cancer 1 |
| Synonyms | DLC1 CFAP81 |
| Synonyms name | cilia and flagella associated protein 81 |
| Locus | 3p22, 2 |
| Discovery year | 1999-05-07 |
| GenBank acession | AB020522 |
| Entrez gene record | 9940 |
| Pubmed identfication | 10213508 |
| RefSeq identity | NM_007337 |
| Havana BLAST/BLAT | OTTHUMG00000131085 |
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