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DMC1 Antibody

DMC1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDMC1 Primary Polyclonal Antibody
Also known asDMC1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDMC1
SpecificityThis is a highly specific antibody against DMC1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DMC1
Gene ID number11144
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Additional proteins involved in the pathway include Nibrin and Dmc1, An alternative spliced form of Dmc1, Dmc1 is specifically involved in meiotic recombination, Nibrin, Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination, Rad51 is essential for mitotic and meiotic recombination, Rad52 is thought to be involved in an early stage of Rad51-mediated recombination, The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway, The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, and its mutation in yeast and mammalian cells results in chromosome loss, designated Dmc1-D, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis, is absent in Nijemegen breakage syndrome (NBS) patients, is deleted for a region between the two motifs involved in nucleotide binding, which complexes with Mre11 and Rad50, DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DMC 1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specic homologous recombination yeast, DMC1 homologue, DMC1H, DMC1_HUMAN, HsLim15, LIM15, MGC150472, MGC150473, Meiotic recombination protein DMC1/LIM15 homolog, dJ199H16, 1, disrupted meiotic cDNA 1 homolog
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDMC1
Short nameDMC1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDMC1 (Antibody to)
Alternative techniqueantibodies
Identity 2927
Gene DMC1
Long gene name DNA meiotic recombinase 1
Synonyms gene name DMC1 (dosage suppressor of mck1, meiosis-specific homologous recombination (yeast) , yeast homolog) meiosis-specific homologous recombination DMC1 dosage suppressor of mck1 homolog
Synonyms LIM15
Locus 22q13, 1
Discovery year 1999-10-29
GenBank acession D63882
Entrez gene record 11144
Pubmed identfication 8602360 8590282 17541404
RefSeq identity NM_007068
Havana BLAST/BLAT OTTHUMG00000151088

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