| Long name | DNA PK/PRKDC Primary Polyclonal Antibody |
| Also known as | DNA PK/PRKDC PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | DNA PK/PRKDC |
| Specificity | This is a highly specific antibody against DNA PK/PRKDC |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DNA PK |
| Gene ID number | 5591 |
| Tested Applications | IF(IHC-P), IHC-P |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity | Mouse, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs), DNA PKcs is a serine/threonine protein kinase whose activity is greatly stimulated by its recruitment to DNA breaks by the Ku heterodimer, DNA PK is the key component of the non-homologous end-joining (NHEJ) pathway of DSB repair in mammalian cells |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | DNA-PK catalytic subunit, DNA-PKcs, DNAPK, DNAPK catalytic subunit, DNPK1, HYRC, HYRC1, PRKDC, PRKDC, PRKDC_HUMAN, Protein Kinase DNA Activated Catalytic Polypeptide, Variant, XRCC 7, XRCC7, p350, p460, DNA-dependent protein kinase catalytic subunit |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | DNA PK/PRKDC |
| Short name | DNA PK/PRKDC Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Desoxyribonucleic acid-activated, catalytic polypeptide (Antibody to), Desoxyribonucleic acid PK/protein kinase |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-PKcs and DNAPK and DNPK1 and HYRC and HYRC1 and IMD26 and p350 and XRCC7, DNA-activated, PRKDC and IDBG-408612 and ENSG00000253729 and 5591, PRKDC and IDBG-644289 and ENSBTAG00000017019 and 512740, Prkdc and IDBG-135771 and ENSMUSG00000022672 and 19090, alcohol group as acceptor, alcohol group as acceptor and also this GO :0019899: enzyme binding and also this GO :0044822: poly(A) RNA binding, alcohol group as acceptor and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0019899 and enzyme binding and molecular function this GO :0030098 and lymphocyte differentiation and biological process this GO :0031648 and protein destabilization and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033152 and immunoglobulin V(D)J recombination and biological process this GO :0033153 and T cell receptor V(D)J recombination and biological process this GO :0035234 and ectopic germ cell programmed cell death and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048511 and rhythmic process and biological process this GO :0070419 and nonhomolo this GO us end joining complex and cellular component this GO :0072431 and signal transduction involved in mitotic G1 DNA damage checkpoint and biological process, catalytic polypeptide, nuclei, this GO :0000723 and telomere maintenance and biological process this GO :0001756 and somitogenesis and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0002326 and B cell lineage commitment and biological process this GO :0002328 and pro-B cell differentiation and biological process this GO :0002360 and T cell lineage commitment and biological process this GO :0003677 and DNA binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004677 and DNA-dependent protein kinase activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005958 and DNA-dependent protein kinase-DNA ligase 4 complex and cellular component this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006303 and double-strand break repair via nonhomolo this GO us end joining and biological process this GO :0006464 and cellular protein modification process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007420 and brain development and biological process this GO :0007507 and heart development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004677: DNA-dependent protein kinase activity and also this GO :0005488: binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008134: transcription factor binding and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004677: DNA-dependent protein kinase activity, this GO :0005488: binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008134: transcription factor binding, this GO :0016772: transferase activity, this GO :0016773: phosphotransferase activity, this GO :0019899: enzyme binding, this GO :0044822: poly(A) RNA binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773: phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, protein kinase |
| Identity | 9413 |
| Gene | PRKDC |
| Long gene name | DNA-activated, catalytic polypeptide , protein kinase |
| Synonyms gene | HYRC HYRC1 |
| Synonyms | DNPK1 p350 DNAPK XRCC7 DNA-PKcs |
| Locus | 8q11, 21 |
| Discovery year | 1993-11-09 |
| Entrez gene record | 5591 |
| Pubmed identfication | 7638222 |
| RefSeq identity | NM_001081640 |
| Havana BLAST/BLAT | OTTHUMG00000164239 |
| Locus Specific Databases | LRG_162 |
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