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DNA PKcs ANTIBODY

DNA PKcs ANTIBODY size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDNA PKcs Primary Polyclonal Antibody
Also known asDNA PKcs PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDNA PKcs
SpecificityThis is a highly specific antibody against DNA PKcs
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DNA PKcs
Gene ID number5591
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D, Also involved in modulation of transcription, Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA, DHX9, Found at the ends of chromosomes, HSPCA, Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination, May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage, Must be bound to DNA to express its catalytic properties, PARP1, POU2F1, Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, Phosphorylates DCLRE1C, Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C), Recognizes the substrate consensus sequence [ST]-Q, Required to protect and align broken ends of DNA, SRF, The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step, WRN, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, c-Abl/ABL1, c-jun/JUN, c-myc/MYC and RFA2, histone H1, p53/TP53, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion, thereby regulating DNA damage response mechanism, Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DNA-PK catalytic subunit, DNA-PKcs, DNAPK, DNAPK catalytic subunit, DNPK1, HYRC, HYRC1, PRKDC, PRKDC, PRKDC_HUMAN, Protein Kinase DNA Activated Catalytic Polypeptide, Variant, XRCC 7, XRCC7, p350, p460, DNA-dependent protein kinase catalytic subunit
Gene targetDNA PKcs
Short nameDNA PKcs ANTIBODY
Alternative nameDesoxyribonucleic acid PKcs (Antibody to)

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