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DNase I Antibody

DNase I Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDNase I Primary Polyclonal Antibody
Also known asDNase I PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDNase I
SpecificityThis is a highly specific antibody against DNase I
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DNase I
Gene ID number1773
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A DNase I-like enzyme appears to catalyze the degradation of chromatin to oligo- and mononucleosomes during apoptosis, A recent study has demonstrated an endonuclease with activity and antigenicity indistinguishable from DNase I in thymocytes, DNase I attacks each strand of DNA independently and the cleavage sites are random, DNase I is a Ca2+ and Mg2+ dependant endonuclease, DNase I is an endonuclease that hydrolyzes double-stranded or single stranded DNA preferentially at sites adjacent to pyrimidine nucleotides, DNase I is synthesized in the pancreas and stored in zymogen granules, In the form of a bovine pancreatic enzyme preparation, In the presence of Mg ion, It has been used to reduce the viscosity of cystic fibrosis sputum, The product of hydrolysis is a complex mixture of 5'-phosphate mononucleotides and oligonucleotides, and it was the first DNase for which a specific protein inhibitor was characterized, cells susceptible to apoptosis, it occupies an important place in the history of protein chemistry and enzymology: it was the first enzyme to be recognized as specific for DNA, it was the first DNase to be crystallized, 2 kb long with 9 exons separated by 8 introns, Deoxyribonuclease I gene is approximately 3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DNAS1_HUMAN, DNASE 1, DNASE1, DNL 1, DNL1, DNase I lysosomal, DNaseI, DRNI, Deoxyribonuclease 1, Deoxyribonuclease I, Deoxyribonuclease1, DeoxyribonucleaseI, Dornase alfa, Human urine deoxyribonuclease I, RNASE1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDNase I
Short nameDNase I Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDNase I (Antibody to)
Alternative techniqueantibodies
Identity 2959
Gene DNASE1L3
Long gene name deoxyribonuclease 1 like 3
Synonyms gene name deoxyribonuclease I like 3
Synonyms DNAS1L3 LSD
Synonyms name DNase gamma
Locus 3p14, 3
Discovery year 1997-05-15
GenBank acession AF047354
Entrez gene record 1776
Pubmed identfication 9205125 9714828 14646506
RefSeq identity NM_004944
Havana BLAST/BLAT OTTHUMG00000159153

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