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DOG1 Antibody (TMEM16A)

DOG1 Antibody (TMEM16A) size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenDOG1 (TMEM16A)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the DOG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis DOG1 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q5XXA6
PurityAntigen affinity
Description ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes, ANO1/DOG1 has eight transmembrane domains, Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer, This gene belongs to a family of membrane proteins containing 8 transmembrane segments, Tumor-amplified and overexpressed sequence 2 (TMEM16A), allowing other negatively charged species to permeate, also known as oral cancer overexpressed 2 (ORAOV2), an antidiarrhoeal, and Discovered on gastrointestinal stromal tumors protein 1 (DOG1) is a protein that in humans is encoded by the ANO1 gene, and it is mapped to 11q13, and it is though to be responsible for a voltage-sensitive calcium-activated chloride current, inhibits this channel, its pore is large and non-selective, 3, Anoctamin-1 (ANO1)
ImmunogenAn amino acid sequence from the C-terminus of human ANO1/TMEM16A/DOG1 (KVLMVELFMREEQDKQQ) was used as the immunogen for this DOG1 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DOG1 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetDOG1 (TMEM16A)
Short nameDOG1 Antibody (TMEM16A)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDOG1 (Antibody to) (TMEM16A)
Alternative techniqueantibodies
Identity 21625
Gene ANO1
Long gene name anoctamin 1
Synonyms gene ORAOV2 TMEM16A
Synonyms gene name calcium activated chloride channel , oral cancer overexpressed 2 transmembrane protein 16A anoctamin 1
Synonyms TAOS2 FLJ10261 DOG1
Locus 11q13, 3
Discovery year 2003-10-16
GenBank acession BC033036
Entrez gene record 55107
Pubmed identfication 15067359 18724360 24692353
RefSeq identity NM_018043
Classification Anoctamins
Havana BLAST/BLAT OTTHUMG00000167204

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