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Doublecortin Antibody / DBCN / DCX

Doublecortin Antibody / DBCN / DCX size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenDoublecortin / DBCN / DCX
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
NotesOptimal dilution of the DCX antibody should be determined by the researcher
Added buffer025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2
Intented useThis antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O43602
PurityAntigen affinity
Description In addition, In the developing cortex, Multiple transcript variants encoding different isoforms have been found for this gene, Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules, The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, This gene encodes a member of the doublecortin family, also known as Doublin or Lissencephalin-X, and this interaction is important to proper microtubule function in the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation, is a protein that in humans is encoded by the DCX gene, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, which bind microtubules, Neuronal migration protein Doublecortin
ImmunogenAmino acids 74-100 (QSLRFHQNMELDFGHFDERDKTSRNMR-human) were used as the immunogen for the DCX antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DCX antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetDoublecortin / DBCN / DCX
Short nameDoublecortin Antibody / DBCN / DCX
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDoublecortin (Antibody to) / DBCN / DCX
Alternative techniqueantibodies
Identity 2714
Gene DCX
Long gene name doublecortin
Synonyms gene name X-linked (doublecortin) , doublecortex, lissencephaly
Synonyms SCLH DC LISX DBCN XLIS
Synonyms name doublecortex
Locus Xq23
Discovery year 1998-03-24
GenBank acession AF040254
Entrez gene record 1641
Pubmed identfication 9489699 9489700
RefSeq identity NM_178153
Classification Doublecortin superfamily
Havana BLAST/BLAT OTTHUMG00000022204

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