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DPYD Antibody, ALEXA FLUOR 594

DPYD Antibody, ALEXA FLUOR 594 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 594 Conjugated, DPYD Polyclonal Antibody
Also known asAnti-DPYD PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated with 594, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenDPYD
SpecificityThis is a highly specific antibody against DPYD
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DPYD
Gene ID Number1806
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs, DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU, DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU, Leukopenia, Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil, Specifically, This reaction includes stomatitis, Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene, a deficiency of DPYD leads to an accumulation of uracil and thymine, also known as hereditary thymine-uraciluria or familial pyrimidinemia, and neurologic symptoms, cerebellar ataxia, diarrhea, fever, hair loss, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression, marked weight loss, progressing to semicoma, thrombocytopenia, thus, thymine and 5-hydroxymethyluracil, Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine, Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission590nm/617nm
Synonyms DPD
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation 594, ALEXA FLUOR®, Alexa Fluor
ConjugatedAlexa conjugate 1
Gene targetDPYD
Short nameDPYD Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 594
Alternative name ALEXA FLUOR 594, DPYD (Antibody to)
Alternative techniqueantibodies
Identity 3012
Gene DPYD
Long gene name dihydropyrimidine dehydrogenase
Locus 1p21, 3
Discovery year 1994-07-07
GenBank acession U20938
Entrez gene record 1806
Pubmed identfication 7713523
RefSeq identity NM_000110
Havana BLAST/BLAT OTTHUMG00000039683
Locus Specific Databases UMD Locus Specific Databases LRG_722

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