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DYRK2 (492CT4.2.4) Monoclonal Antibody

DYRK2 (492CT4.2.4) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name2, 4) Monoclonal Antibody, DYRK2 (492CT4
Also known as2, 4) Monoclonal Antibody, DYRK2 (492CT4
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDYRK2
SpecificityThis is a highly specific antibody against DYRK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number2, 4, 492CT4
SourceThis DYRK2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 105-135 amino acids from human DYRK2
Gene ID number8445
Swiss ProtQ92630
Tested ApplicationsWB
Recommended dilutionsWB(1:100~500)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B, CRMP4/DPYSL3, Can phosphorylate CARHSP1 (in vitro), Can phosphorylate histone H1, DCX, EIF2B5, EIF4EBP1, Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', Functions in part via its role in ubiquitin-dependent proteasomal protein degradation, GLI2, GLI3, GYS1, Inactivates GYS1 by phosphorylation at 'Ser-641', JUN, Likewise, MDM2, MYC, May play a general role in the priming of GSK3 substrates, Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1, NFATC1, Phosphorylates CRMP2/DPYSL2, Phosphorylates EIF2B5 at 'Ser-544', Phosphorylates NFATC1, Phosphorylates SIAH2, Phosphorylates TERT at 'Ser-457', Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2, Promotes proteasomal degradation of GLI2 and GLI3, Promotes the proteasomal degradation of MYC and JUN, TAU/MAPT and KATNA1, and potentially also a second phosphorylation site, and thereby contributes to the induction of apoptosis in response to DNA damage, and thereby increases its ubiquitin ligase activity, and thereby inhibits its accumulation in the nucleus and its transcription factor activity, and thereby plays a role in smoothened and sonic hedgehog signaling, and thereby regulates progress through the mitotic cell cycle and cell proliferation, apoptosis, cell proliferation, enabling its subsequent phosphorylation and inhibition by GSK3B, histone H3 and histone H2B (in vitro), organization of the cytoskeleton and neurite outgrowth, p53/TP53, phosphorylation of NFATC1, promoting TERT ubiquitination by the EDVP complex, thus regulating glycogen synthesis, Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle
Purification method This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DYRK2, Dual specificity tyrosine-phosphorylation-regulated kinase 2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target2, 4) Monoclonal, DYRK2 (492CT4
Short name2, 4) Monoclonal Antibody, DYRK2 (492CT4
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name2, 4) monoclonal (Antibody to), dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (492CT4
Alternative techniqueantibodies
Alternative to gene target DYRK2 and IDBG-45841 and ENSG00000127334 and 8445, DYRK2 and IDBG-634243 and ENSBTAG00000007256 and 514916, Dyrk2 and IDBG-192216 and ENSMUSG00000028630 and 69181, nuclei, this GO :0000151 and ubiquitin ligase complex and cellular component this GO :0000287 and magnesium ion binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004712 and protein serine/threonine/tyrosine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007224 and smoothened signaling pathway and biological process this GO :0016772 and transferase activity, this GO :0000287: magnesium ion binding, this GO :0000287: magnesium ion binding and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004712: protein serine/threonine/tyrosine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004712: protein serine/threonine/tyrosine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0030145: manganese ion binding, this GO :0043130: ubiquitin binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0030145: manganese ion binding and also this GO :0043130: ubiquitin binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030145 and manganese ion binding and molecular function this GO :0030529 and ribonucleoprotein complex and cellular component this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0045725 and positive regulation of glycogen biosynthetic process and biological process this GO :0051534 and negative regulation of NFAT protein import into nucleus and biological process, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Identity 3093
Gene DYRK2
Long gene name dual specificity tyrosine phosphorylation regulated kinase 2
Synonyms gene name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Locus 12q15
Discovery year 1998-10-29
GenBank acession Y09216
Entrez gene record 8445
Pubmed identfication 9748265
Havana BLAST/BLAT OTTHUMG00000169089

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