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Dyskerin Antibody

Dyskerin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDyskerin Primary Polyclonal Antibody
Also known asDyskerin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDyskerin
SpecificityThis is a highly specific antibody against Dyskerin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dyskerin
Gene ID number1736
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen DKC is a rare, GAR1, Missense mutations in the dyskerin gene interfere with normal nuclear localization of dyskerin and cause Dyskeratosis congenita (DKC) (4), NHP2 (NOLA2) and Nop10 for the isomerization of uridine to pseudouridine (1), NHP2 and dyskerin localize to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies (2), The GAR1 gene maps to chromosome 4q25 (5, The NHP2 gene maps to chromosome 5q35, The dyskerin gene maps to chromosome Xq28 (3), X-linked bone marrow disorder characterized by cutaneous hyperpigmentation, atrophy of the testicles and leukoplakia of the oral mucosa, dystrophy of the nails, 3 and encodes a 155-amino acid protein (2, 6), 7), Dyskerin (NAP57) associates with the chaperone protein Nopp140 and forms a small ribonucleoprotein particle with GAR1 (NOLA1)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CBF5 homolog, Cbf5p homolog, DKC, DKC 1, DKC1_HUMAN, DKCX, Dkc1, Dyskeratosis congenita 1, Dyskeratosis congenita 1 dyskerin, Dyskerin, H/ACA ribonucleoprotein complex subunit 4, NAP 57, NAP-57, NAP57, NOLA 4, NOLA4, Nopp140 associated protein of 57 kDa, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, XAP 101, XAP101, snoRNP protein DKC1, CBF5
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDyskerin
Short nameDyskerin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDyskerin (Antibody to)
Alternative techniqueantibodies
Identity 2890
Gene DKC1
Long gene name dyskerin pseudouridine synthase 1
Synonyms gene DKC
Synonyms gene name dyskeratosis congenita 1, dyskerin
Synonyms XAP101 dyskerin NAP57 NOLA4 Cbf5
Synonyms name H/ACA ribonucleoprotein complex subunit 4
Locus Xq28
Discovery year 2001-06-22
GenBank acession AJ224481
Entrez gene record 1736
Pubmed identfication 9590285 9888995
RefSeq identity NM_001363
Classification H/ACA ribonucleoprotein complex
Havana BLAST/BLAT OTTHUMG00000024242
Locus Specific Databases DKC1base: Mutation registry for Hoyeraal-Hreidarsson syndrome Mental Retardation database LRG_55

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