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E3 ubiquitin ligase Antibody

E3 ubiquitin ligase Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameE3 ubiquitin ligase Primary Polyclonal Antibody
Also known asE3 ubiquitin ligase PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenE3 ubiquitin ligase
SpecificityThis is a highly specific antibody against E3 ubiquitin ligase
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range45-95/352
Subcellular locationMitochondrion
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human E3 ubiquitin ligase/RNF218
Gene ID number79594
Swiss ProtQ969V5
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Can mediate DDX58 sumoylation and disrupt its polyubiquitination, Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Inhibits cell growth, Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response, Plays a role in the control of mitochondrial morphology, Promotes mitochondrial fragmentation and influences mitochondrial localization, Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations, The function may implicate its abilty to sumoylate DNM1L, When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis, Exhibits weak E3 ubiquitin-protein ligase activity
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C1orf166, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, MAPL, MUL1, MULAN, Mitochondrial ubiquitin ligase activator of NFKB 1, Mitochondrial-anchored protein ligase, Putative NF-kappa-B-activating protein 266, RING finger protein 218, RNF218, GIDE
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetE3 ubiquitin ligase
Short nameE3 ubiquitin ligase Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameE3 ubiquitin ligase (Antibody to)
Alternative techniqueantibodies
Identity 13890
Gene ITCH
Long gene name itchy E3 ubiquitin protein ligase
Synonyms gene name itchy (mouse homolog) E3 ubiquitin protein ligase itchy E3 ubiquitin protein ligase homolog (mouse)
Synonyms AIP4
Locus 20q11, 22
Discovery year 2001-04-27
GenBank acession AF095745
Entrez gene record 83737
Pubmed identfication 11318614
Classification C2 domain containing
Havana BLAST/BLAT OTTHUMG00000032300
Locus Specific Databases LRG_354

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