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E3 ubiquitin ligase Antibody, ALEXA FLUOR 488

E3 ubiquitin ligase Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, E3 ubiquitin ligase Polyclonal Antibody
Also known asAnti-E3 ubiquitin ligase PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenE3 ubiquitin ligase
SpecificityThis is a highly specific antibody against E3 ubiquitin ligase
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range45-95/352
Subcellular locationMitochondrion
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human E3 ubiquitin ligase/RNF218
Gene ID Number79594
Swiss ProtQ969V5
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Can mediate DDX58 sumoylation and disrupt its polyubiquitination, Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Inhibits cell growth, Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response, Plays a role in the control of mitochondrial morphology, Promotes mitochondrial fragmentation and influences mitochondrial localization, Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations, The function may implicate its abilty to sumoylate DNM1L, When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis, Exhibits weak E3 ubiquitin-protein ligase activity
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms AIP4
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the E3 ubiquitin ligase Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetE3 ubiquitin ligase
Short nameE3 ubiquitin ligase Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, E3 ubiquitin ligase (Antibody to)
Alternative techniqueantibodies
Identity 13890
Gene ITCH
Long gene name itchy E3 ubiquitin protein ligase
Synonyms gene name itchy (mouse homolog) E3 ubiquitin protein ligase itchy E3 ubiquitin protein ligase homolog (mouse)
Locus 20q11, 22
Discovery year 2001-04-27
GenBank acession AF095745
Entrez gene record 83737
Pubmed identfication 11318614
Classification C2 domain containing
Havana BLAST/BLAT OTTHUMG00000032300
Locus Specific Databases LRG_354

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