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E3 ubiquitin ligase Antibody, Cy7 Conjugated

E3 ubiquitin ligase Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, E3 ubiquitin ligase Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenE3 ubiquitin ligase
SpecificityThis is a highly specific antibody against E3 ubiquitin ligase
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range45-95/352
Subcellular locationMitochondrion
SourceKLH conjugated synthetic peptide derived from human E3 ubiquitin ligase/RNF218
Gene ID number79594
Swiss ProtQ969V5
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Can mediate DDX58 sumoylation and disrupt its polyubiquitination, Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Inhibits cell growth, Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response, Plays a role in the control of mitochondrial morphology, Promotes mitochondrial fragmentation and influences mitochondrial localization, Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations, The function may implicate its abilty to sumoylate DNM1L, When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis, Exhibits weak E3 ubiquitin-protein ligase activity
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms C1orf166, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, MAPL, MUL1, MULAN, Mitochondrial ubiquitin ligase activator of NFKB 1, Mitochondrial-anchored protein ligase, Putative NF-kappa-B-activating protein 266, RING finger protein 218, RNF218, GIDE
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetE3 ubiquitin ligase Conjugated
Short name Conjugated, E3 ubiquitin ligase Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, E3 ubiquitin ligase (Antibody to)
Alternative techniqueantibodies

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