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EAAT4 Antibody

EAAT4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameEAAT4 Primary Polyclonal Antibody
Also known asEAAT4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenEAAT4
SpecificityThis is a highly specific antibody against EAAT4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EAAT4
Gene ID number6511
Tested Applications FCM, IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Although EAAT5 shares the structural homologies of the EAAT family, EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum, EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina, EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering, a process that is essential for terminating the postsynaptic action of glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities, which is caused by the accumulation of amino acid neurotransmitters, Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names High affinity neuronal glutamate transporter, MGC33092, MGC43671, Sodium dependent glutamate/aspartate transporter, Solute carrier family 1 high affinity aspartate/glutamate transporter member 6, Solute carrier family 1 member 6, Excitatory amino acid transporter 4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetEAAT4
Short nameEAAT4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEAAT4 (Antibody to)
Alternative techniqueantibodies
Identity 10944
Gene SLC1A6
Long gene name solute carrier family 1 member 6
Synonyms gene name member 6 , solute carrier family 1 (high affinity aspartate/glutamate transporter)
Synonyms EAAT4
Locus 19p13, 12
Discovery year 1997-02-05
Entrez gene record 6511
Pubmed identfication 7791878
RefSeq identity NM_005071
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000183351

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