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EAAT4 Antibody, Biotin Conjugated

EAAT4 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, EAAT4 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenEAAT4
SpecificityThis is a highly specific antibody against EAAT4
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human EAAT4
Gene ID number6511
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Although EAAT5 shares the structural homologies of the EAAT family, EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum, EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina, EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering, a process that is essential for terminating the postsynaptic action of glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities, which is caused by the accumulation of amino acid neurotransmitters, Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms EAAT4
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetEAAT4 Conjugated
Short name Conjugated, EAAT4 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, EAAT4 (Antibody to)
Alternative techniqueantibodies
Identity 10944
Gene SLC1A6
Long gene name solute carrier family 1 member 6
Synonyms gene name member 6 , solute carrier family 1 (high affinity aspartate/glutamate transporter)
Locus 19p13, 12
Discovery year 1997-02-05
Entrez gene record 6511
Pubmed identfication 7791878
RefSeq identity NM_005071
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000183351

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