Filters

EGFRvIII Antibody

EGFRvIII Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameEGFRvIII Primary Polyclonal Antibody
Also known asEGFRvIII PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenEGFRvIII
SpecificityThis is a highly specific antibody against EGFRvIII
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1-50/1081
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EGFRvIII
Gene ID number1956
Swiss ProtP00533
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, Also directly phosphorylates other proteins like RGS16, Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin, BTC/betacellulin, Isoform 2 may act as an antagonist of EGF action, Known ligands include EGF, Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues, May also activate the NF-kappa-B signaling cascade, PI3 kinase-AKT, PLCgamma-PKC and STATs modules, TGFA/TGF-alpha, The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling, amphiregulin, epigen/EPGN, epiregulin/EREG and HBEGF/heparin-binding EGF, Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names EGFR, ERBB1, Epidermal growth factor receptor, HER1, NISBD2, PIG61, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, mENA, ERBB
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetEGFRvIII
Short nameEGFRvIII Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEGFRvIII (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter