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EGFRvIII Antibody, Cy3 Conjugated

EGFRvIII Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, EGFRvIII Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenEGFRvIII
SpecificityThis is a highly specific antibody against EGFRvIII
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1-50/1081
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human EGFRvIII
Gene ID number1956
Swiss ProtP00533
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, Also directly phosphorylates other proteins like RGS16, Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin, BTC/betacellulin, Isoform 2 may act as an antagonist of EGF action, Known ligands include EGF, Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues, May also activate the NF-kappa-B signaling cascade, PI3 kinase-AKT, PLCgamma-PKC and STATs modules, TGFA/TGF-alpha, The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling, amphiregulin, epigen/EPGN, epiregulin/EREG and HBEGF/heparin-binding EGF, Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms EGFR, ERBB1, Epidermal growth factor receptor, HER1, NISBD2, PIG61, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, mENA, ERBB
Properties 1 of the EGFRvIII Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetEGFRvIII Conjugated
Short name Conjugated, EGFRvIII Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, EGFRvIII (Antibody to)
Alternative techniqueantibodies

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