| Alternative name 1 | Clone: 1B9, Mab anti-, EIF2AK2 |
| Alternative name 2 | Clone: 1B9, Mab antibody-, EIF2AK2 |
| Alternative name 3 | Clone: 1B9, Mab antibody-, EIF2AK2 |
| Alternative name 4 | anti-E2AK2 Clone: 1B9 |
| Alternative name 5 | E2AK2 Clone: 1B9 |
| Clonality | Monoclonal Antibody |
| Description | Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, If used correctly and according the protocol, in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications, This is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against |
| Storage and handling | Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°, for longer periods - at -20 , C, Generally |
| Advisory | For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container, Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom, To keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| French translation | anticorps |
| Gene target | Monoclonal 1B9, EIF2AK2 |
| Short name | Mouse Monoclonal antibody- Clone: 1B9, EIF2AK2 |
| Technique | Monoclonals or monoclonal antibodies, mouses, Mouse |
| Species | Mouses, Mouse |
| Alternative name | Mouse monoclonal (Antibody to)-, clonality: 1B9, eukaryotic translation initiation factor 2-a phosphorylation catalyst 2 |
| Alternative technique | murine |
| Alternative to gene target | DNA-templated and biological process this GO :0006412 and translation and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008601 and protein phosphatase type 2A regulator activity and molecular function this GO :0009615 and response to virus and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, EIF2AK1 and PKR and PPP1R83 and PRKR, EIF2AK2 and IDBG-44867 and ENSG00000055332 and 5610, EIF2AK2 and IDBG-632472 and ENSBTAG00000008703 and 347700, Eif2ak2 and IDBG-199014 and ENSMUSG00000024079 and 19106, nuclei, this GO :0000186 and activation of MAPKK activity and biological process this GO :0001819 and positive regulation of cytokine production and biological process this GO :0003725 and double-stranded RNA binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004694 and eukaryotic translation initiation factor 2alpha kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003725: double-stranded RNA binding, this GO :0003725: double-stranded RNA binding and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004694: eukaryotic translation initiation factor 2alpha kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004715: non-membrane spanning protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008601: protein phosphatase type 2A regulator activity and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004694: eukaryotic translation initiation factor 2alpha kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004715: non-membrane spanning protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008601: protein phosphatase type 2A regulator activity, this GO :0016772: transferase activity, this GO :0044822: poly(A) RNA binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0044822: poly(A) RNA binding, transferring phosphorus-containing groups and molecular function this GO :0017148 and negative regulation of translation and biological process this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019048 and modulation by virus of host morphology or physiology and biological process this GO :0019054 and modulation by virus of host process and biological process this GO :0019058 and viral life cycle and biological process this GO :0030683 and evasion or tolerance by virus of host immune response and biological process this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0032874 and positive regulation of stress-activated MAPK cascade and biological process this GO :0033689 and negative regulation of osteoblast proliferation and biological process this GO :0035455 and response to interferon-alpha and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045071 and negative regulation of viral genome replication and biological process this GO :0045087 and innate immune response and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051607 and defense response to virus and biological process this GO :1900225 and regulation of NLRP3 inflammasome complex assembly and biological process this GO :1901224 and positive regulation of NIK/NF-kappaB signaling and biological process this GO :1901532 and regulation of hematopoietic progenitor cell differentiation and biological process this GO :1902033 and regulation of hematopoietic stem cell proliferation and biological process this GO :1902036 and regulation of hematopoietic stem cell differentiation and biological process, eukaryotic translation initiation factor 2-alpha kinase 2 |
| Identity | 9437 |
| Gene | EIF2AK2 |
| Long gene name | eukaryotic translation initiation factor 2 alpha kinase 2 |
| Synonyms gene | PRKR |
| Synonyms gene name | interferon-inducible double stranded RNA dependent , protein kinase |
| Synonyms | PKR EIF2AK1 PPP1R83 |
| Synonyms name | protein phosphatase 1, regulatory subunit 83 |
| Locus | 2p22, 2 |
| Discovery year | 1992-12-04 |
| GenBank acession | BC057805 |
| Entrez gene record | 5610 |
| Pubmed identfication | 1351683 |
| RefSeq identity | NM_002759 |
| Classification | Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT | OTTHUMG00000100962 |
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