| Long name | 39) Monoclonal Antibody, 4, EIF2AK3 (1385CT582 |
| Also known as | 39) Monoclonal Antibody, 4, EIF2AK3 (1385CT582 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | EIF2AK3 |
| Specificity | This is a highly specific antibody against EIF2AK3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1385CT582, 4, 39 |
| Source | This EIF2AK3 antibody is generated from a mouse immunized with a recombinant protein conjugated synthetic peptide between 530-850 amino acids from human EIF2AK3 |
| Gene ID number | 9451 |
| Swiss Prot | Q9NZJ5 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:250-1:1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, Involved in control of mitochondrial morphology and function, Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1), and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | EIF2AK3, Eukaryotic translation initiation factor 2-alpha kinase 3, HsPEK, PERK, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, WRS, PEK |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 39) Monoclonal, 4, EIF2AK3 (1385CT582 |
| Short name | 39) Monoclonal Antibody, 4, EIF2AK3 (1385CT582 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 39) monoclonal (Antibody to), 4, eukaryotic translation initiation factor 2-a phosphorylation catalyst 3 (1385CT582 |
| Alternative technique | antibodies |
| Alternative to gene target | EIF2AK3 and IDBG-60518 and ENSG00000172071 and 9451, EIF2AK3 and IDBG-634760 and ENSBTAG00000000184 and 535820, Eif2ak3 and IDBG-155036 and ENSMUSG00000031668 and 13666, PEK and PERK and WRS, Plasma membranes, this GO :0001501 and skeletal system development and biological process this GO :0001503 and ossification and biological process this GO :0002063 and chondrocyte development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004694 and eukaryotic translation initiation factor 2alpha kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005623 and cell and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006412 and translation and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006983 and ER overload response and biological process this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0007029 and endoplasmic reticulum organization and biological process this GO :0007595 and lactation and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004694: eukaryotic translation initiation factor 2alpha kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004694: eukaryotic translation initiation factor 2alpha kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019899: enzyme binding, this GO :0019903: protein phosphatase binding, this GO :0042802: identical protein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019899: enzyme binding and also this GO :0019903: protein phosphatase binding and also this GO :0042802: identical protein binding, transferring phosphorus-containing groups and molecular function this GO :0017148 and negative regulation of translation and biological process this GO :0019217 and regulation of fatty acid metabolic process and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0030073 and insulin secretion and biological process this GO :0030282 and bone mineralization and biological process this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0031016 and pancreas development and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0031642 and negative regulation of myelination and biological process this GO :0032055 and negative regulation of translation in response to stress and biological process this GO :0032057 and negative regulation of translational initiation in response to stress and biological process this GO :0032092 and positive regulation of protein binding and biological process this GO :0032933 and SREBP signaling pathway and biological process this GO :0034976 and response to endoplasmic reticulum stress and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process, eukaryotic translation initiation factor 2-alpha kinase 3 |
| Identity | 3255 |
| Gene | EIF2AK3 |
| Long gene name | eukaryotic translation initiation factor 2 alpha kinase 3 |
| Synonyms | PEK PERK |
| Locus | 2p11, 2 |
| Discovery year | 1999-06-14 |
| GenBank acession | AF110146 |
| Entrez gene record | 9451 |
| Pubmed identfication | 10026192 10575235 |
| RefSeq identity | NM_004836 |
| Havana BLAST/BLAT | OTTHUMG00000155046 |
| Locus Specific Databases | LRG_1024 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue