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EIF6 Antibody / EIF3A

EIF6 Antibody / EIF3A size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenEIF6 / EIF3A
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0
NotesOptimal dilution of the EIF3A antibody should be determined by the researcher
Intented useThis EIF3A antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P56537
PurityAntigen affinity
Description (1998) mapped the ITGB4BP gene to 20q11, (2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6, (2008) demonstrated that mammalian eIF6 is required for efficient initiation of translation in vivo, By fluorescence in situ hybridization, Ceci et al, EIF6 interacts in the cytoplasm with RACK1, EIF6 is bound to free 60S but not to 80S subunits, Eif6-null mouse embryos were lethal at preimplantation, Furthermore, Gandin et al, Heterozygous mice had 50% reduction of eIF6 levels in all tissues, In the cytoplasm, Sanvito et al, a receptor for activated protein kinase C, also called EIF3A or ITGB4BP, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression, is a human gene, 2, EIF6 (Eukaryotic Translation Initiation Factor 6)
ImmunogenAmino acids 66-210 of human EIF6/EIF3A were used as the immunogen for the EIF3A antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the EIF3A antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
LocalizationNuclear and cytoplasmic
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetEIF6 / EIF3A
Short nameEIF6 Antibody / EIF3A
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEIF6 (Antibody to) / EIF3A
Alternative techniqueantibodies
Identity 3271
Gene EIF3A
Long gene name eukaryotic translation initiation factor 3 subunit A
Synonyms gene EIF3 EIF3S10
Synonyms gene name 150/170kDa eukaryotic translation initiation factor 3, eukaryotic translation initiation factor 3, subunit 10 theta, subunit A
Synonyms eIF3-theta eIF3-p170 KIAA0139 eIF3a TIF32
Locus 10q26, 11
Discovery year 1998-11-26
GenBank acession U78311
Entrez gene record 8661
Pubmed identfication 9054404 8590280
RefSeq identity NM_003750
Classification Eukaryotic translation initiation factor 3
Havana BLAST/BLAT OTTHUMG00000019144

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