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EPH receptor A4 Antibody

EPH receptor A4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameEPH receptor A4 Primary Polyclonal Antibody
Also known asEPH receptor A4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenEPH receptor A4
SpecificityThis is a highly specific antibody against EPH receptor A4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range570-620/986
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EphA4
Gene ID number2043
Swiss ProtP54764
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis, Additionally, Highly promiscuous, In addition to its role in axonal guidance plays a role in synaptic plasticity, In the nervous system, May also control the segregation of motor and sensory axons during neuromuscular circuit development, Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections, Rap and Rho GTPases activity, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Upon activation by ephrin ligands, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium, leading to contact-dependent bidirectional signaling into neighboring cells, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation, Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names EK8, EPH-like kinase 8, EPHA4, Ephrin type-A receptor 4, HEK8, TYRO1, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK, SEK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Description 2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell
Gene targetEPH receptor A4
Short nameEPH receptor A4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEPH receptor A4 (Antibody to)
Alternative techniqueantibodies
Identity 3385
Gene EPHA1
Long gene name EPH receptor A1
Synonyms gene EPHT EPHT1
Synonyms gene name EphA1
Synonyms EPH
Locus 7q34-q35
Discovery year 1989-05-16
GenBank acession M18391
Entrez gene record 2041
Pubmed identfication 9267020
Classification Sterile alpha motif domain containing Fibronectin type III domain containing EPH receptors
Havana BLAST/BLAT OTTHUMG00000155894

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