| Long name | ALEXA FLUOR 350 Conjugated, EPO Receptor (Tyr368) Antibody |
| Also known as | Anti-EPO Receptor Tyr368 PAb ALEXA FLUOR 350 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 350, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | EPO Receptor Tyr368 |
| Specificity | This is a highly specific antibody against EPO Receptor Tyr368 |
| Modification | Phosphorylation |
| Modification Site | Tyr368 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368 |
| Gene ID Number | 2057 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | A functional EPOR is found in the cardiovascular system, Defects in the EPOR may produce erythroleukemia and familial erythrocytosis, EPOR-S (soluble form), In animal studies, The stimulated EPOR appears to have a role in erythroid cell survival, There are several isoforms including: EPOR-F (full length), Upon erythropoietin (EPO) binding, and EPOR-T (truncated form), and data suggest that the EPO/EPO receptor system plays an important role in cardiac function, including endothelial cells and cardiomyocytes, phosphatidylinositol 3-kinase and STAT transcription factors, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis, The erythropoietin receptor (EPOR) is a member of the cytokine receptor family |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 343nm/442nm |
| Synonyms | EP |
| Properties | ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | ALEXA FLUOR 350, Alexa Fluor |
| Gene target | EPO Receptor (Tyr368) |
| Short name | EPO Receptor (Tyr368) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 350 |
| Alternative name | ALEXA FLUOR 350, erythropoietin Receptor (Tyr368) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0048678 and response to axon injury and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071474 and cellular hyperosmotic response and biological process this GO :1902219 and negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress and biological process this GO :1902251 and negative regulation of erythrocyte apoptotic process and biological process this GO :2001258 and negative regulation of cation channel activity and biological process, EP and MVCD2, EPO and IDBG-31941 and ENSG00000130427 and 2056, EPO and IDBG-640493 and ENSBTAG00000003430 and 280784, Epo and IDBG-205003 and ENSMUSG00000029711 and 13856, Extracellular, protein kinase activator activity, this GO :0001666 and response to hypoxia and biological process this GO :0005128 and erythropoietin receptor binding and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007566 and embryo implantation and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009651 and response to salt stress and biological process this GO :0009986 and cell surface and cellular component this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030295 and protein kinase activator activity and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033189 and response to vitamin A and biological process this GO :0033574 and response to testosterone and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042541 and hemoglobin biosynthetic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043249 and erythrocyte maturation and biological process this GO :0043627 and response to estrogen and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045893 and positive regulation of transcription, this GO :0005128: erythropoietin receptor binding, this GO :0005128: erythropoietin receptor binding and also this GO :0005179: hormone activity and also this GO :0005515: protein binding and also this GO :0030295: protein kinase activator activity, this GO :0005179: hormone activity, this GO :0005515: protein binding, this GO :0030295: protein kinase activator activity, erythropoietin |
| Identity | 3415 |
| Gene | EPO |
| Long gene name | erythropoietin |
| Locus | 7q22, 1 |
| Discovery year | 2001-06-22 |
| GenBank acession | X02157 |
| Entrez gene record | 2056 |
| Pubmed identfication | 9799793 3838366 |
| RefSeq identity | NM_000799 |
| Classification | Endogenous ligands |
| Havana BLAST/BLAT | OTTHUMG00000152121 |
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